ABINEURON-NP TABLETS

Each tablet of ABINEURON-NP contains:

1. Pregabalin 75mg
   • Pregabalin is an anticonvulsant and neuropathic pain agent.
2. Nortriptyline 10mg
   • Nortriptyline is a tricyclic antidepressant (TCA) with analgesic properties.
3. Methylcobalamin 1500mcg
   • Methylcobalamin is an active form of Vitamin B12, essential for nerve health and regeneration.

Uses of ABINEURON-NP Tablets:

This combination is typically prescribed for:

• Neuropathic pain (due to conditions like diabetic neuropathy, post-herpetic neuralgia)
• Fibromyalgia
• Chronic pain with a neuropathic component
• Sciatica and nerve-related disorders
• Adjunct therapy in patients with nerve damage or Vitamin B12 deficiency

Abineuron NP  Tablet is a combination of medicines used to treat long-lasting (chronic) pain caused by nerve damage due to diabetes, shingles, or spinal cord injury. It reduces pain and its associated symptoms such as mood changes, sleep problems, and tiredness. It is thought to work by interfering with pain signals that travel through the damaged nerves and the brain. It also contains nutritional supplements that are essential for improving nerve conduction.
Taking  Abineuron NP Tablet regularly will improve your physical and social functioning and overall quality of life. It takes a few weeks to work so you need to take it regularly even if you feel it is not doing any good. Once your symptoms have gone you should still keep taking the medicine until your doctor advises you to stop.

Pharmacology of ABINEURON-NP Tablets:

1. Pregabalin
   • Mechanism of Action: Pregabalin binds to calcium channels in the central nervous system (CNS), reducing neurotransmitter release and modulating pain signals.
   • Onset of Action: Typically, effects are noticeable within a few days, but maximum benefit can take 2-4 weeks.
   • Duration: This combination provides action throughout the day.
2. Nortriptyline
   • Mechanism of Action: Nortriptyline inhibits the reuptake of norepinephrine and serotonin, increasing their availability at synapses, and also exhibits analgesic properties by modulating pain pathways in the CNS.
   • Onset of Action: Antidepressant effects may take 2-4 weeks, but analgesic effects may be noticeable sooner.
3. Methylcobalamin
   • Mechanism of Action: Methylcobalamin supports the regeneration of damaged nerves, promotes myelin sheath repair, and plays a role in the synthesis of neurotransmitters.

Dosage and Administration of ABINEURON-NP Tablets:

• Adults: One tablet once daily, preferably at night to minimize daytime sedation, or as directed by a physician.
• Route of Administration: Oral
• Special Populations:
  • Elderly: Start at a lower dose due to increased risk of sedation and dizziness.
  • Pregnancy and Lactation: Use only if the potential benefit justifies the potential risk to the fetus or baby. Consult with a healthcare provider before use.

Contraindications of ABINEURON-NP Tablets:

• Hypersensitivity to pregabalin, nortriptyline, methylcobalamin, or any excipients in the formulation.
• Recent myocardial infarction or significant cardiac arrhythmias (nortriptyline).
• Glaucoma or urinary retention (due to anticholinergic effects of nortriptyline).

Warnings and Precautions of ABINEURON-NP Tablets:

• CNS Depression: Pregabalin and nortriptyline may cause sedation, dizziness, or drowsiness, so patients should avoid driving or operating heavy machinery.
• Suicidal Thoughts: Antidepressants like nortriptyline may increase the risk of suicidal thoughts, especially in young adults.
• Weight Gain: Both pregabalin and nortriptyline may cause weight gain with prolonged use.
• Liver and Kidney Function: Adjust doses in patients with impaired renal or hepatic function.
• Serotonin Syndrome: Although rare, the combination with other serotonergic agents may increase the risk of serotonin syndrome.

Drug Interactions of ABINEURON-NP Tablets:

• CNS Depressants: Increased sedative effects when taken with alcohol, opioids, or benzodiazepines.
• MAO Inhibitors: Nortriptyline should not be combined with MAO inhibitors due to the risk of hypertensive crisis.
• Anticholinergics: Additive effects with other drugs that have anticholinergic properties, increasing the risk of constipation, urinary retention, or confusion.
• Diuretics: Combining with diuretics may increase the risk of electrolyte imbalances.

Adverse Effects of ABINEURON-NP Tablets:

• Common:
  • Pregabalin: Dizziness, somnolence, dry mouth, edema, blurred vision.
  • Nortriptyline: Dry mouth, constipation, weight gain, drowsiness, dizziness.
  • Methylcobalamin: Well-tolerated; occasional gastrointestinal disturbances like nausea.
• Serious:
  • Pregabalin: Angioedema, hypersensitivity reactions.
  • Nortriptyline: Cardiac arrhythmias, orthostatic hypotension, serotonin syndrome (rare).
  • Methylcobalamin: No major serious side effects at recommended doses.

Pregnancy and Lactation

• Pregnancy: Limited data; use only if the benefits outweigh risks. Pregabalin has been shown to cause fetal harm in animal studies, though human studies are limited.
• Lactation: Pregabalin and nortriptyline can pass into breast milk. Use with caution while breastfeeding.

Overdose

• Pregabalin: Symptoms include excessive sedation, confusion, and agitation.
• Nortriptyline: Symptoms include cardiac arrhythmias, severe hypotension, agitation, delirium, and seizures.
• Methylcobalamin: No known toxicity with high doses, but seek medical attention for any adverse effects.

In the case of overdose, seek immediate medical attention.

Storage

• Store in a cool, dry place at temperatures below 25°C.
• Protect from moisture and direct sunlight.
• Keep out of reach of children.

Drug Category : Combination medication

Therapeutic Category : Neuropathic pain management

Avilable Dosage Type : Tablets

Habit Forming : No

Driving : Unsafe

Ailment : Diabetic Peripheral Neuropathy, Postherpetic Neuralgia

Frequently Asked Questions (FAQs) about ABINEURON-NP Tablets:

1. What is the role of Pregabalin in ABINEURON-NP Tablet combination?
   Pregabalin is an anticonvulsant that helps to reduce neuropathic pain by modulating pain signals in the brain and spinal cord.
2. What does Nortriptyline do in ABINEURON-NP Tablet combination?
   Nortriptyline is a tricyclic antidepressant that also has pain-relieving properties, particularly for neuropathic pain. It helps by increasing levels of certain chemicals in the brain that regulate mood and pain.
3. What is the function of Methylcobalamin in ABINEURON-NP Tablet?
   Methylcobalamin is an active form of Vitamin B12, crucial for nerve repair and protection. It helps regenerate damaged nerves and can reduce nerve-related symptoms like tingling, numbness, and pain.
4. Can this ABINEURON-NP Tablet combination be used for diabetic neuropathy?
   Yes, this combination is often prescribed for treating neuropathic pain associated with diabetes (diabetic neuropathy), as it addresses both pain relief and nerve repair.
5. How long does ABINEURON-NP Tablet take for this medication to work?
   While some patients may experience relief within the first week, maximum benefits, especially for neuropathic pain, may take 2-4 weeks of regular use.
6. Can I take ABINEURON-NP Tablet with other painkillers?
   You should consult your doctor before combining this with other pain medications, as there could be additive effects or potential drug interactions.
7. What are the side effects of ABINEURON-NP Tablet I should watch for?
   Common side effects include dizziness, drowsiness, dry mouth, and constipation. Serious side effects include heart rhythm issues, confusion, and allergic reactions like swelling.
8. Can I stop taking ABINEURON-NP Tablet medication abruptly?
   No, you should not stop taking pregabalin or nortriptyline abruptly, as it can lead to withdrawal symptoms like irritability, sleep disturbances, or increased pain. Always consult your doctor before discontinuing.
9. ABINEURON-NP Tablet Is it safe for elderly patients?
   Caution is required in elderly patients as they may be more sensitive to side effects such as dizziness, sedation, or heart rhythm disturbances. Dose adjustments may be necessary.
10. Can ABINEURON-NP Tablet combination be used for conditions other than neuropathy?
    Yes, this combination can also be used for other conditions involving chronic pain with a nerve component, like sciatica or fibromyalgia, but always under the guidance of a healthcare provider.

Note:-If you have additional concerns or questions, consult your healthcare provider for personalized advice.

Seller Information

Manufactured By:

EXODRUG,

A GMP & GLP Certified Company,

Plot No. 19, Industrial Area, Khadeen,

Parwanoo, Solon (Dt.) (H.P.)-173220.

Marketed By:

SOREX LABS

Neminath CHS, Tejpal Road,

Vile Parle (E), Mumbai-400057, India.

For Query & Complaints E-mail: support@sorexlabs.in

TM- Trade mark under Registration