EZOMAX-DSR capsules

How Ezomax-Dsr capsule works:

1. Esomeprazole 40mg (As Gastro Resistant Pellets)
   • Esomeprazole is a proton pump inhibitor (PPI) that reduces the amount of acid produced in the stomach.
2. Domperidone 30mg (As Prolonged Release Pellets)
   • Domperidone is a dopamine antagonist with prokinetic properties that help in controlling nausea and vomiting and promotes gastric emptying.

Uses of Ezomax-Dsr capsule:

This combination is primarily used for the treatment of:

• Gastro Esophageal Reflux Disease (GERD)
• Chronic Dyspepsia
• Erosive Esophagitis
• Zollinger-Ellison syndrome
• Reflux-associated nausea, vomiting, and delayed gastric emptying

Ezomax-Dsr capsule Pharmacology :

1. Esomeprazole
   • Mechanism of Action: Esomeprazole works by selectively inhibiting the H+/K+ ATPase enzyme in the gastric parietal cells, leading to suppression of gastric acid secretion.
   • Onset of Action: 1-2 hours
   • Duration: Acid suppression lasts for around 24 hours.

1. Domperidone
   • Mechanism of Action: Domperidone works by blocking dopamine receptors in the gut and chemoreceptor trigger zone, thereby increasing the motility of the stomach and intestines without affecting gastric secretions.
   • Onset of Action: 30-60 minutes
   • Duration: The sustained-release formulation provides effects lasting for around 24 hours.

Ezomax-Dsr capsule Dosage and Administration

• Adults: One capsule daily, preferably before meals or as directed by a physician.
• Route of Administration: Oral
• Special Populations:
  • Elderly: Adjust dose cautiously, especially in patients with impaired kidney or liver function.
  • Children: Not recommended for children under 12 years of age.
  • Pregnancy and Lactation: Use only if clearly needed and prescribed by a physician. Caution in breastfeeding due to domperidone excretion in breast milk.

Contraindications

• Known hypersensitivity to esomeprazole, domperidone, or any excipient.
• Patients with significant cardiac conditions such as QT prolongation.
• Domperidone should be avoided in patients with severe hepatic impairment or significant electrolyte disturbances.
• Contraindicated in patients with mechanical obstruction or perforation of the gastrointestinal tract.

Warnings and Precautions

• Cardiovascular Risk: Domperidone has been associated with an increased risk of arrhythmias, particularly in patients older than 60 or those taking high doses.
• Liver Function: Use with caution in patients with hepatic impairment. Regular monitoring may be necessary.
• Kidney Function: Esomeprazole may need dosage adjustments in patients with severe renal impairment.
• Long-term use: Prolonged use of esomeprazole may lead to low magnesium levels, bone fractures, or Clostridium difficile infections.

Drug Interactions

• Esomeprazole: May interact with drugs like clopidogrel, warfarin, and certain antifungals (ketoconazole, itraconazole).
• Domperidone: Avoid co-administration with drugs that prolong QT interval (e.g., amiodarone, erythromycin) or inhibit CYP3A4 (e.g., ketoconazole).
• Combined Use: Caution with other prokinetic agents or acid-suppressing drugs.

Adverse Effects of EZOMAX-Dsr Capsule

• Common:
  • Esomeprazole: Headache, nausea, abdominal pain, diarrhea.
  • Domperidone: Dry mouth, dizziness, headache.
• Serious:
  • Esomeprazole: Hypomagnesemia, Clostridium difficile-associated diarrhea, fractures with long-term use.
  • Domperidone: QT prolongation, ventricular arrhythmias, galactorrhea, and gynecomastia (rare).

Storage

• Store in a cool, dry place at temperatures below 25°C.
• Keep away from moisture and direct sunlight.
• Keep out of reach of children.

Drug Category : Proton pump inhibitor

Therapeutic Class : Gastrointestinal medication

Avilable Dosage Type : Capsule

Habit Forming : Not addictive

Ailment : GERD, Erosive Esophagitis,Chronic, Dyspepsia and Zollinger Ellison Syndrome.

Frequently Asked Questions (FAQs) about EZOMAX-DSR capsule:

1. What is the role of Esomeprazole in Ezomax-Dsr capsule?
   Esomeprazole is a proton pump inhibitor that reduces stomach acid production, helping relieve symptoms of acid reflux, GERD, and esophagitis.
2. What does Domperidone do in Ezomax-Dsr capsule?
   Domperidone increases the motility of the stomach and intestines, preventing nausea, vomiting, and promoting gastric emptying.
3. Can I take this Ezomax-Dsr capsule during pregnancy?
   Use during pregnancy is not recommended unless deemed necessary by a healthcare provider. Domperidone, especially, should be used with caution.
4. How long does Ezomax-Dsr capsule take to start working?
   Esomeprazole takes about 1-2 hours to start reducing acid, and domperidone starts working within 30-60 minutes to improve gastric motility.
5. Can I take Ezomax-Dsr capsule with other medications?
   Ezomax-Dsr capsule combination may interact with several medications, including blood thinners, antifungals, and medications affecting heart rhythm. Always inform your doctor about other drugs you are taking.
6. How should I take Ezomax-Dsr capsule?
   Take one Ezomax-Dsr capsule daily before meals, unless otherwise directed by your doctor. Swallow it whole with water, do not crush or chew the capsule.
7. What should I do if I miss a dose of Ezomax-Dsr capsule?
   If you miss a dose, take it as soon as you remember. However, if it is near the time of your next dose, skip the missed dose. Do not double the dose to make up for it.
8. What are the risks of long-term use of Ezomax-Dsr capsule?
   Prolonged use of esomeprazole can lead to an increased risk of fractures, low magnesium levels, and vitamin B12 deficiency. Long-term use of domperidone can increase the risk of cardiac side effects.
9. Can Ezomax-Dsr capsule affect heart rhythm?
   Yes, domperidone has been associated with QT prolongation, which can affect heart rhythm, especially in those with underlying heart conditions or electrolyte imbalances.
10. Ezomax-Dsr capsule is it safe for elderly patients?
    Caution is required in elderly patients, especially those with heart, liver, or kidney problems. Regular monitoring may be necessary to avoid complications.

Note:- If you have any other questions or concerns, always consult your healthcare provider for personalized advice.

Seller Information

Manufactured By:

ZENOMED HEALTHCARE PVT LTD,

An ISO & GMP Certified Unit,

No. 70-73, First Cross, Rainbow Nagar, Vazhuthavuran Pattai,

 Navamalkapper, Villupuram (Dt.) Tamilnadu-605102.

Marketed By:

SOREX LABS

Neminath CHS, Tejpal Road, Vile Parle (E), Mumbai-400057, India.

For Query & Complaints E-mail: support@sorexlabs.in

TM- Trade mark under Registration